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However, other studies have reported much stronger associations between perceived breathlessness and lung function (eg, r 088 by Burdon, Juniper, Killian, Hargreave, & Campbell, 1982) While correlations re ect the relative association of two variables, they do not re ect other important information for asthma management (eg, how frequently can a patient detect when his/her air ow has diminished signi cantly), to the point at which medications should be used Finally, behavioral follow-through actually using medications when the need to do so is identi ed is yet another independent step in appropriate self-management There are alarming reports of signi cant delays in seeking treatment, despite patients reported awareness of decreased respiratory function in the 24 to 48 hours prior to obtaining treatment (eg, Mol no, Nannini, Martelli, & Slutsky, 1991)..

The companies provide that service through well standardised and easy-to-deploy interfaces and business practices Disruptive technologies are introduced by new companies Users active involvement appears in the mobile and wireless arena People s willingness to participate, driven by both technological and social reasons, produces a noticeable impact on the ways in which companies have dialogue with end-users Mobile and wireless applications and services, managed on an expanding range of open platforms and services, are increasingly shaped by user dynamics Users have no or less money to spend on mobile-based services However, a positive attitude towards novel ideas pushes the development of business models forward These are characterised by highly innovative commercial proposals and complex and distributed business-to-business value networks enabling a rich offer of new services In addition, ethical and political aspirations towards a more inclusive information society push innovations.

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evidence have implicated hypoactivity of the left prefrontal cortex in the pathophysiology of depression Even so, it is clear that the prefrontal region is just one component of a distributed network that is important for regulating mood Although rTMS appears promising, carefully controlled and blinded studies with appropriate sham conditions are few and far between, and a variety of methodological issues remain to be addressed before claims about ef cacy of rTMS for treating depression can be established (see Wasserman & Lisanby, 2001) The WADA Technique The intracarotid amobarbital procedure (IAP) was rst developed by Wada to lateralize language function in the evaluation of patients with epilepsy, but it more recently has been used to predict the degree of postoperative amnesia in patients being considered for epilepsy surgery (Trenerry & Loring, 1995) Although the precise procedure varies, the typical IAP involves the injection of suf cient barbiturate (eg.

People with disabilities or elderly are recognised as niches of promising businesses; forward-looking entrepreneurs look at them to build highly personalised, contextaware mobile and wireless applications and services Security and privacy measures are still strong but don t produce uniform effects The public debate over what is legal, ethical or sensible is active Commercial companies, open source groups and consumer groups stand behind different and competing solutions It is dif cult to achieve a unique approach, which in turn gives opportunities to innovators in the eld..

, sodium amytal, sodium brevital) into a catheter placed in the internal carotid artery to produce a contralateral hemiplegia Memory and language testing is typically conducted before, during, and after the period of drug action The procedure generally results in a temporary impairment in hemispheric functions subserved by the middle cerebral artery During injection of the language-dominant hemisphere, the patient becomes globally aphasic Both hemispheres are studied sequentially in the same procedure In addition to predicting hemisphere dominance for language, behavioral performance during the WADA procedure has been shown to predict seizure outcome and verbal memory decline after unilateral temporal lobectomy (Loring et al, 1994; Trenerry & Loring, 1995), and is useful for determining whether the nonaffected hemisphere can support memory function in isolation WADA test results correlate well with hippocampal volume asymmetries in unilateral onset cases (Loring et al, 1993).

One signi cant drawback of the WADA procedure is that it is highly invasive Because of this, it is used exclusively in patients undergoing diagnostic evaluation for brain surgery in which determination of language lateralization or memory support is important for predicting outcome In recent years, there has been substantial interest in determining whether less invasive functional imaging procedures can be used to provide the same information as the IAP Several studies using fMRI (Binder et al, 1996; Desmond et al, 1995; Lehericy et al, 2000), transcranial Doppler ultrasound (Knecht et al, 1998; Rihs, Sturzenegger, Gutbrod, Schroth, & Mattle, 1999), magnetic source imaging (Breier, Simos,.

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