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Implementations that are more integrated into the Mac OS X environment include Carbon emacs, based on Apple s Darwin port and Andrew Choi s Mac OS port; and XEmacs 1914, which is based on GNU emacs 1859 for Macintosh by Marc Parmet and facilitates accessing the Codewarrior development environment over AppleEvents Don t confuse this XEmacs with the XEmacs implementation available under most UNIX flavors; the X here stands for the X in Mac OS X Each of these emacs versions implements different features On one end of the spectrum is the terminal-mode implementation This version is simple and clean, integrates well with the BSD development tools, has a minimal memory requirement (compared to the other versions), and is launched from the command line The disadvantage is that it is terminal based, does not display text highlighting or multicolor fonts, and does not support mouse interaction.

Arduino PG et al Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management Oral Dis 2006 May;12(3):254 70 [PMID: 16700734] Kolokotronis A et al Herpes simplex virus infection, with particular reference to the progression and complications of primary herpetic gingivostomatitis Clin Microbiol Infect 2006 Mar;12(3):202 11 [PMID: 16451405]

2 Aphthous Ulcer (Canker Sore, Ulcerative Stomatitis)

dict.Add("Utah", "Salt Lake City"); dict.Add("Vermont", "Montpelier"); dict.Add("Virginia", "Richmond"); dict.Add("Washington", "Olympia"); dict.Add("West Virginia", "Charleston"); dict.Add("Wisconsin", "Madison"); dict.Add("Wyoming", "Cheyenne"); // access a state Console.WriteLine("The capital of Massachusetts is {0}", dict["Massachusetts"]); } } }

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Aphthous ulcers are very common and easy to recognize Their cause remains uncertain, although an association with human herpesvirus 6 has been suggested Found on nonkeratinized mucosa (eg, buccal and labial mucosa and not attached gingiva or palate), they may be single or multiple, are usually recurrent, and appear as painful small (usually 1 2 mm, but sometimes 1 2 cm) round ulcerations with yellow-gray fibrinoid centers surrounded by red halos The painful stage lasts 7 10 days; healing is completed in 1 3 weeks Treatment is nonspecific Topical corticosteroids (triamcinolone acetonide, 01%, or fluocinonide ointment, 005%) in an adhesive base (Orabase Plain) do appear to provide symptomatic relief Other topical therapies shown to be effective in controlled studies include diclofenac 3% in hyaluronan 25%, doxymycine-cyanoacrylate, mouthwashes containing the enzymes amyloglucosidase and glucose oxidase, and amlexanox 5% oral paste A 1-week tapering course of prednisone (40 60 mg/d) has also been used successfully Cimetidine maintenance therapy may be useful in patients with recurrent aphthous ulcers Thalidomide has been used selectively in recurrent aphthous ulcerations in HIV-positive patients Large or persistent areas of ulcerative stomatitis may be secondary to erythema multiforme or drug allergies, acute herpes simplex, pemphigus, pemphigoid, epidermolysis bullosa acquisita, bullous lichen planus, Beh et s disease, or inflammatory bowel disease SCC may occasionally present in this fashion When the diagnosis is not clear, incisional biopsy is indicated

Akintoye SO et al Recurrent aphthous stomatitis Dent Clin North Am 2005 Jan;49(1):31 47, vii viii [PMID: 15567359] Kroidl A et al Prevalence of oral lesions and periodontal diseases in HIV-infected patients on antiretroviral therapy Eur J Med Res 2005 Oct 18;10(10):448 53 [PMID: 16287607] Letsinger JA et al Complex aphthosis: a large case series with evaluation algorithm and therapeutic ladder from topicals to thalidomide J Am Acad Dermatol 2005 Mar;52(3 Pt 1):500 8 [PMID: 15761429]

Sore throat Fever Anterior cervical adenopathy Tonsillar exudate Focus is to treat group A -hemolytic streptococcus infection to prevent rheumatic sequelae

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Pharyngitis and tonsillitis account for over 10% of all office visits to primary care clinicians and 50% of outpatient antibiotic use The most appropriate management continues to be debated because some of the issues are deceptively complex, but consensus has increased in recent years The main concern is determining who is likely to have a group A -hemolytic streptococcal infection (GABHS), as this can lead to subsequent complications such as rheumatic fever and glomerular nephritis A second public health policy concern is reducing the extraordinary cost (both in dollars and in the development of antibiotic-resistant S pneumoniae) in the United States associated with unnecessary and unrecommended antibiotic use Questions now being asked: Is there still a role for culturing a sore throat, or have the rapid antigen tests supplanted this procedure under most circumstances Are clinical criteria alone a sufficient basis for decisions about which patients should be given antibiotics Should any patient receive any antibiotic other than penicillin (or erythromycin if penicillin-allergic) For how long should treatment be continued Numerous well-done studies in the past few years as well as increasing experience with rapid laboratory tests for detection of streptococci (eliminating the delay caused by culturing) appear to make a consensus approach more possible

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