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ications and to some extent in prognosis Basically, this classi cation divides seizures into two types partial, in which a focal or localized onset can be discerned, and generalized, in which the seizures appear to begin bilaterally It is also useful clinically and etiologically to separate epilepsies that originate as truly generalized electrical discharges in the brain from those which spread secondarily from a focus to become generalized The primary generalized epilepsies are a group of somewhat diverse, age-dependent phenotypes that are characterized by generalized 25- to 4-Hz bifrontally predominant spikes or polyspike-and-slow-wave discharges that arise without underlying structural abnormalities In most instances, these individuals have normal intelligence What is most signi cant is that a genetic component underlies many of these disorders (see below) By contrast, seizures that begin locally and evolve into generalized tonic-clonic seizures, termed secondary generalized seizures, generally have no such genetic component and are usually the result of underlying brain disease, either acquired or due to congenital malformations or metabolic defects Quite often, the initial focal phase is missed, leading to misdiagnosis Individuals with secondary generalized epilepsies tend to have more diffuse brain dysfunction and may have a progressive course These seizures may be of different types, including atonic, myoclonic, and tonic-clonic seizures An increas-

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The bit width of a memory module is very important; the term refers to how much information the processor can access from or write to memory in a single cycle A memory bank represents the number of memory modules required to match the data bus width of the processor For example, a Pentium 4 processor has a 64-bit data bus You have the option of adding up to 4GB of RAM on the newer motherboards If you wanted to you could add two 2GB memory modules, four 1GB memory modules, or some number smaller Each memory module would take a single memory bank

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ing frequency and severity of this group of disorders with age re ects the accumulation of focal insults from trauma, strokes, and other damage Partial or focal seizures are further classi ed as simple when consciousness is undisturbed and complex when consciousness is altered or impaired Simple partial seizures are further classi ed according to their main clinical manifestations motor, sensory, autonomic, or psychic When one of these subjective manifestations precedes the progression of the attack to a loss of consciousness, it is referred to as an aura and has commonly been regarded as a premonitory sign or warning of the impending seizure In reality, the aura represents the initial phase of a focal seizure; in some instances it may constitute the entire epileptic attack Generalized seizures are of two types convulsive and nonconvulsive The common convulsive type is the tonic-clonic (grand mal) seizure Less common is a purely tonic, purely clonic, or clonic-tonic-clonic generalized seizure The classic nonconvulsive generalized seizure is the brief lapse of consciousness or absence (petit mal); included also under this heading are minor motor phenomena such as brief myoclonic, atonic, or tonic seizures The classi cation of seizures and of the epilepsies is constantly being modi ed In one of the latest versions, the so-called syndromic classi cation (Epilepsia 30:389, 1989), an attempt has been made to incorporate all of the seizure types and epileptic syndromes and to categorize them not only as partial and generalized but also according to their age of onset, their primary or secondary nature, the evidence of cortical loci of the epileptogenic lesions, and the many clinical settings in which they occur This classi cation is semantically dif cult and, in our view, too complicated as yet for general clinical application Since many epileptic syndromes share overlapping features, it is often not possible to t a newly diagnosed case of epilepsy into a speci c category in this new classi cation (Manford et al) The commission is engaged in an extensive revision of terminology and classi cation in the eld of epilepsy Until this revision is widely adopted, we propose to begin our discussion with the 1981 classi cation of seizures, with certain modi cations and additions, to be followed by a consideration of a number of well-de ned epilepsies and epileptic syndromes In the discussions that follow, the various types of seizures are viewed largely in the context of the age at which they occur An approximation of the distribution of the seizure types for each age epoch, obtained and aggregated from several sources, is shown in Fig 16-1 There has also been substantial progress in de ning the molecular basis of familial and hereditary epilepsies over the last decade; it is highly likely that these new insights will lead to further modi cation of both the clinical classi cations and the therapeutic management of the epilepsies (see further on).

GENERALIZED SEIZURES The Generalized Tonic-Clonic Seizure (Grand Mal)

Media servers The media servers are connected to the tape library either directly as a Network Attached Storage (NAS) device or through a Fibre Channel (FC) Storage Area Network (SAN) switch Media servers house the Oracle Secure Backup media manager A minimum of two media servers is preferred for high availability Performance can scale when you add more, provided other bottlenecks do not exist Backup network The backup network is the route of the data from where it currently resides (ie, the Exadata Database Machine) to the backup device (ie, the tape library) The performance of the backup and restore operations depends on the throughput of the backup network and the throughput of the processes consuming/generating the backup traffic at the network end-points The slowest link in the network path limits the overall throughput The Database Machine connects to the media servers using the InfiniBand ports available on the InfiniBand switch or through the 1 GigE and 10 GigE ports available on the database servers Connecting through the InfiniBand ports will give you the best network throughput When the 1 GigE option is used, rest assured, the bottleneck for backup performance in most cases will be the 1 GigE network The network protocol used is TCP/IP for both, InfiniBand as well as Gigabit Ethernet

As has already been pointed out, it is important, whenever possible, to distinguish between a primary (generalized) type of seizure, with widespread EEG abnormalities at the onset, and a secondarily generalized type, which begins as a focal or partial seizure and then becomes generalized

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A memory bank refers to a match between the processor s data bus width and RAM s bit width If you are using a 64-bit processor, one 64-bit DIMM makes

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